How SAM-e Reduces Fibro Symptoms


AM-e (pronounced “samm-ee”) has been prescribed in Europe for decades. It was originally developed in 1952 in Italy as a treatment for depression; however, patients also reported pain relief and inflammation relief as a side effect. In addition to depression, SAM-e has demonstrated positive results for treatment of other conditions according to renowned Italian physician Ascanio Polimeni. European doctors prescribe SAM-e not only for depression but also for chronic fatigue syndrome (CFS) and fibromyalgia. This article is part of our Best Supplements For Fibromyalgia series. Be sure to check out our other articles for more helpful information about managing fibromyalgia symptoms and issues.

SAM-e and Fibromaylgia



Luckily, people with fibromyalgia (over 12 million in the US alone) and their doctors are starting to take note: SAM-e is now available as an over-the-counter supplement in the US, and multiple FDA-sponsored clinical trials have demonstrated its effectiveness for many of these conditions—including fibromyalgia. These results have been confirmed by multiple renowned medical research facilities, including the Mayo Clinic, the University of Maryland Medical Center, and the NYU Langone Medical Center.

But what is SAM-e, and how does it work? More importantly, how can you take it in a manner that’s affordable and offers high bioavailability?

What Is SAM-e?

SAM-e is a chemical compound that occurs naturally in the body. It’s formed by a combination of two molecules, each crucial for your body’s normal functioning: methionine, an amino acid that serves as a building block for many proteins necessary for bodily function; and ATP, the main energy source for all the cells in your body.

Note that despite the fact that SAM-e normally is produced naturally by the body, people with methionine, folate (vitamin B9), and/or vitamin B12 deficiencies almost always develop a deficiency in SAM-e as well. Furthermore, multiple studies have shown that people with fibromyalgia demonstrate severe deficiencies in these and other crucial chemical compounds. This means that if you’re suffering from fibromyalgia, it’s extremely likely that your body is deficient in SAM-e; and because SAM-e is generally widespread in the body and critical for over 100 complex biochemical reactions, this deficiency is causing your body to perform less than optimally—even causing or worsening your fibromyalgia symptoms

How Does SAM-e Work To Reduce Fibromyalgia Symptoms?

SAM-e’s exact mechanism of action isn’t fully understood. Still, due to its performance in clinical trials and in treated patients, doctors and researchers have come up with several likely hypotheses.

One hypothesis is that SAM-e “donates” a part of its chemical structure to your central nervous system (CNS) receptors in a chemical reaction. This reaction increases the brain’s production of certain neurotransmitters associated with wellbeing and mood stability, including serotonin, dopamine, and norepinephrine. There are multiple clinical studies documenting the effectiveness of SAM-e as an antidepressant—many people find it to be as or more effective than standard prescription antidepressants (including tricyclic antidepressants and SSRIs), but without their the unpleasant side effects. Note that while we are not trying to perpetuate the myth that fibromyalgia is caused by (or is no more than) depression, there’s good evidence that improved mental/psychological health can reduce the frequency and intensity of fibromyalgia symptoms.

Other researchers have noted that SAM-e demonstrates the same anti-inflammatory and pain-relief effects of NSAIDS (non-steroidal anti-inflammatory drugs) such as Advil, Tylenol, and Aspirin—but without their deadly side effects! Finally, there’s clinical evidence that people with fibromyalgia exhibit extensive mitochondrial damage throughout the body (especially in the muscles and spinal cord). Because ATP production takes place in the mitochondria, this means that people with fibromyalgia have less ATP—or energy—in their muscles, causing fibro’s agonizing muscle pain and stiffness.

How Can I Take SAM-e?

Luckily for those of us suffering from the symptoms of fibromyalgia, Every Day Optimal has developed a revolutionary new product designed specifically for fibromyalgia pain. It’s called Fibromyalgia CBD, and it contains a blend of supplements—including SAM-e, alpha lipoic acid, rhodiola rosea, malic acid, (and 10+ others) and cannabidiol oil (CBD). Unlike any other supplements or multivitamins, Fibromyalgia CBD is specially formulated with a blend of chemical compounds proven to treat every single symptom of fibromyalgia, along with added pure full spectrum CBD, known for its revolutionary effectiveness for treating pain, inflammation, anxiety, depression, sleep issues and much more.

Even better? The vitamins and minerals that make up Fibromyalgia CBD were lab tested to ensure that each element is made from the highest quality products available in the form that maximizes each compound’s bioavailability. This means that your body is actually receiving—and using—a full dose of SAME-e, as well as additional supplements  that help SAM-e perform to its highest possible degree. Fibromyalgia CBD was developed by a fibromyalgia sufferer for fellow fibromyalgia sufferers—it’s not another Big Pharma scam to make money off others’ pain with poor-quality supplements.

Finally, the Every Day Optimal CBD offers a 100% Money Back Guarantee that covers your most recent order for 30 days! So, when I say this program is “zero risk,” We really mean it—unlike the majority of “Miracle Drug” promises out there.


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Every Day Optimal brings you the latest and greatest in trending news and helpful information for an optimized, maximized lifestyle.

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